The Effects of Oxalis corniculata l. Extract against MPTP Induced Oxidative Stress in Mouse Model of Parkinson’s Disease
نویسندگان
چکیده
Neurodegeneration refers to a condition of neuronal death occurring as a result of progressive disease of long term. It involves degeneration of circumscribed group of neurons that may be functionally or neuroanatomically connected. Parkinson’s disease (PD) is a chronic, progressive neurological disorder. Recent studies have indicated that a part of active compounds extracted from herbal medicines, herbal extracts and herbal formulations have effects on Parkinson disease models in vitro and in vivo. The present study deals with the effects of Oxalis corniculata L. extract against MPTP induced oxidative stress in mouse model of Parkinson’s disease. O. corniculata extract at doses of 250 and 500 mg/kg along with MPTP administration significantly restored the peroxides and antioxidant levels to near normal in the brains of the test animals. The standard drugs L-dopa + carbidopa combination also significantly restored the peroxides and antioxidant levels to near normal.
منابع مشابه
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